Cevimeline (trade name Evoxac ) is a parasympathomimetic and muscarinic agonist ,[1] with particular effect on M1 and M3 receptors . It is used in the treatment of dry mouth and especially associated with Sjögren's syndrome .
Mechanism of action [ ]
By activating the M3 receptors of the parasympathetic nervous system , cevimeline stimulates secretion by the salivary glands , thereby alleviating dry mouth.
Side effects [ ]
Known side effects include nausea , vomiting , diarrhea , excessive sweating , rash , headache , runny nose , cough , drowsiness , hot flashes , blurred vision , and difficulty sleeping .[2]
Contraindications include asthma and angle closure glaucoma .[citation needed ]
See also [ ]
Pilocarpine — a similar parasympathomimetic medication for dry mouth (xerostomia )
Bethanechol — a similar muscarinic parasympathomimetic with longer-lasting effect
References [ ]
^ Ono M, Takamura E, Shinozaki K, et al. (July 2004). "Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study". Am. J. Ophthalmol . 138 (1): 6–17. doi :10.1016/j.ajo.2004.02.010 . PMID 15234277 .
^ [1] MedicineNet: Cevimeline. Accessed 10/12/2007
External links [ ]
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