Metharbital was patented in 1905 by Emil Fischer working for Merck.[2] It was marketed as Gemonil by Abbott Laboratories. It is a barbiturateanticonvulsant, used in the treatment of epilepsy.[3][4] It has similar properties to phenobarbital.
History[]
1952 Gemonil was introduced by Abbott Laboratories.
1990 Abbott stopped marketing.
Synthesis[]
Metharbital can be synthesized from 2,2-diethylmalonic acid and O-methylisourea.[5][6][2]
References[]
^"Metharbital". The Comparative Toxicogenomics Database.
^ abUS 782742, Fischer E, "Trisubstituted barbituric acids and process of making them.", issued 14 February 1905, assigned to E. Merck
^Shorvon SR, Fish DR, Perucca E, Dodson WE, eds. (2004). The Treatment of Epilepsy (2nd ed.). Blackwell. ISBN0-632-06046-8.
^Resor SR (1991). The Medical Treatment of Epilepsy. Marcel Dekker. ISBN0-8247-8549-5.
^Halpern A, Jones JW (June 1949). "The characterization of the trialkylbarbiturates". Journal of the American Pharmaceutical Association. 38 (6): 352–5. doi:10.1002/jps.3030380619. PMID18151714.
^Snyder JA, Link KP (1953). "Preparation and Characterization by Alkaline Methanolysis of 5,5-Diethyl-4-(tetraacetyl-β-D-glucosyloxy)-2,6(1,5)-pyrimidinedione". Journal of the American Chemical Society. 75 (8): 1881. doi:10.1021/ja01104a030.