Emylcamate (marketed as Striatran by Merck ) is an anxiolytic and muscle relaxant . It was patented in the US in 1961 (US Patent 2,972,564) and advertised for the treatment of anxiety and tension. It was claimed to be superior to meprobamate , which was the market leader at the time. It is no longer prescribed.
A study of the drug's effects in mice was done in 1959. It concluded that at 50 mg/kg emylcamate gave a 63% decrease in motor activity compared with meprobamate's 32% decrease, a doubling in effective potency. The therapeutic index in mice was also established:
Meprobamate
Emylcamate
Effect
175
123
ED50 (mg/kg)
600
550
LD50 (mg/kg)
3.4
4.4
Therapeutic index
Emylcamate also has a faster intra-parenteral onset then meprobamate, 3 minutes compared with 35.
[1]
References [ ]
^ Melander B (1959). "Emylcamate, A Potent Tranquillizing Relaxant". Journal of Medicinal and Pharmaceutical Chemistry . 1 (5): 443–457. doi :10.1021/jm50006a003 .
Further reading [ ]
External links [ ]
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