List of investigational sleep drugs

This is a list of investigational sleep drugs, or drugs for the treatment of sleep disorders that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Insomnia[]

GABA_A receptor potentiators[]

• EVT-201 – GABA_A receptor positive allosteric modulator[1]
• Lorediplon (GF-015535-00) – GABA_A receptor positive allosteric modulator [2]
• Zuranolone (SAGE-217) – GABA_A receptor positive allosteric modulator [3]

Orexin receptor antagonists[]

• Daridorexant (nemorexant; ACT-541468) – dual OX₁ and OX₂ receptor antagonist [4]
• Seltorexant (MIN-202, JNJ,42847922, JNJ-922) – selective OX₂ receptor antagonist [5]
• Vornorexant (ORN-0829, TS-142) – dual OX₁ and OX₂ receptor antagonist [6]

Melatonin receptor agonists[]

• Piromelatine (Neu-P11) – melatonin receptor agonist and 5-HT_1A and 5-HT_1D receptor agonist [7]

Nociceptin receptor agonists[]

• (IMB-115, IT-1315, S-117957, V-117957) – nociceptin receptor agonist [8][9]

Hypersomnia/narcolepsy[]

Orexin receptor agonists[]

• Danavorexton (TAK-925) – OX₂ receptor-selective agonist via IV infusion^[1][10]
• TAK-994 – OX₂ receptor agonist pill (orally available) ^[1]

Monoaminergics[]

• (THN-102) – modafinil (dopamine reuptake inhibitor) and flecainide (antiarrhythmic) combination [11]
• Mazindol controlled release (NLS-1001, NLS-1) – norepinephrine-predominant serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI)[12]
• Reboxetine (AXS-12) – norepinephrine reuptake inhibitor (NRI) [13]

GHB receptor agonists[]

• (sodium oxybate controlled release) – GHB and GABA_B receptor agonist [14]
• (oxybate mixed salt solution) – GHB and GABA_B receptor agonist [15]

GABA_A receptor inhibitors[]

• Pentylenetetrazole (BTD-001) – GABA_A receptor negative allosteric modulator [16]

See also[]

• List of investigational drugs

References[]