Renanolone ATC code show 3α-hydroxy-5β-pregnane-11,20-dione
CAS Number PubChem CID ChemSpider UNII Formula C 20 H 30 O 4 Molar mass −1 3D model (JSmol ) show CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(O)[C@H]3C(=O)C[C@]12C
show InChI=1S/C20H30O4/c1-11(21)15-5-6-16-14-4-3-12-9-13(22)7-8-20(12,24)18(14)17(23)10-19(15,16)2/h12-16,18,22,24H,3-10H2,1-2H3/t12-,13-,14+,15-,16+,18-,19-,20-/m1/s1
Key:ICICFVFEPDWWAQ-MNYWXNLXSA-N
Renanolone (INN ), or 11-ketopregnanolone , also known as 5β-pregnan-3α-ol-11,20-dione , is a synthetic [citation needed neuroactive steroid which is described as a general anesthetic but was never introduced for clinical use.[1] isomers , alfaxolone and alfadolone , are also general anesthetics, and are known to act as positive allosteric modulators of the GABAA receptor , a property which is likely the case for renanolone as well.
Chemistry [ ] See also [ ] References [ ]
^ Hill RA, Makin HL, Kirk DN, Murphy GM (23 May 1991). Dictionary of Steroids ISBN 978-0-412-27060-4
show General anesthetics (N01A )
Inhalational
Chloroethane (ethyl chloride) ‡ Chloroform ‡ Cyclopropane ‡ Desflurane Diethyl ether ‡ Enflurane Ethylene ‡ Fluroxene ‡ Halothane # Isoflurane # Methoxyflurane Methoxypropane ‡ Nitrous oxide # Sevoflurane Trichloroethylene ‡ Vinyl ether ‡ Xenon Injection
Phenols Barbiturates Opioids
Morphine # Oxycodone Anileridine ‡ Embutramide ‡ Fentanyl # Alfentanil Phenoperidine Remifentanil ÷Sufentanil Arylcyclohexylamines Neuroactive steroids Others
# WHO-EM ‡ Withdrawn from marketClinical trials :
† Phase III § Never to phase III
show GABA A receptor positive modulatorsAlcohols
Butanol Chloralodol Chlorobutanol (cloretone) Ethanol (alcohol) (alcoholic drink )Ethchlorvynol Isobutanol Isopropanol Menthol Methanol Methylpentynol Pentanol Petrichloral Propanol tert -Butanol (2M2P)tert -Pentanol (2M2B)Tribromoethanol Trichloroethanol Triclofos Trifluoroethanol Barbiturates Benzodiazepines Carbamates Flavonoids
Ampelopsin (dihydromyricetin) Apigenin Baicalein Baicalin Catechin EGC EGCG Hispidulin Luteolin Skullcap constituents (e.g., baicalin )Wogonin Imidazoles Kava constituents
Desmethoxyyangonin Kavain Methysticin Yangonin Monoureides Neuroactive steroids Nonbenzodiazepines Phenols
Fospropofol Propofol Thymol Piperidinediones Pyrazolopyridines Quinazolinones Volatiles /gases
Acetone Acetophenone Acetylglycinamide chloral hydrate Aliflurane Benzene Butane Butylene Centalun Chloral Chloral betaine Chloral hydrate Chloroform Cryofluorane Desflurane Dichloralphenazone Dichloromethane Diethyl ether Enflurane Ethyl chloride Ethylene Fluroxene Gasoline Halopropane Halothane Isoflurane Kerosine Methoxyflurane Methoxypropane Nitric oxide Nitrogen Nitrous oxide Norflurane Paraldehyde Propane Propylene Roflurane Sevoflurane Synthane Teflurane Toluene Trichloroethane (methyl chloroform) Trichloroethylene Vinyl ether Others/unsorted
3-Hydroxybutanal Avermectins (e.g., ivermectin )Bromide compounds (e.g., lithium bromide , potassium bromide , sodium bromide )Carbamazepine Chloralose Chlormezanone Clomethiazole DEABL Dihydroergolines (e.g., dihydroergocryptine , , dihydroergotamine , ergoloid (dihydroergotoxine) )Efavirenz Etazepine Etifoxine Fenamates (e.g., flufenamic acid , mefenamic acid , niflumic acid , tolfenamic acid )Fluoxetine Flupirtine Hopantenic acid Lanthanum Lavender oil Lignans (e.g., 4-O-methylhonokiol , honokiol , magnolol , obovatol )Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine) Safranal Seproxetine Stiripentol (e.g., sulfonmethane (sulfonal) , tetronal , trional )
Terpenoids (e.g., borneol )Topiramate Valerian constituents (e.g., isovaleric acid , isovaleramide , valerenic acid , )Unsorted benzodiazepine site positive modulators: α-Pinene See also: Receptor/signaling modulators • GABA receptor modulators • GABA metabolism/transport modulators
