Insulin-like growth factor receptor

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The insulin-like growth factor receptors (IGFRs) include the following two receptors:

Insulin-like growth factor 1 receptor (IGF-1R)
Insulin-like growth factor 2 receptor (IGF-2R)

See also[]

Insulin-like growth factor
Insulin-like growth factor 1
Insulin-like growth factor 2
Insulin-like growth factor-binding protein

References[]

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRG (1 2 3 4 5 6 7)
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled & Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

Signaling peptide/protein receptor modulators

AdipoR₁	Agonists: Peptide: Adiponectin ; Non-peptide: AdipoRon (–)-Arctigenin Arctiin Gramine Matairesinol Antagonists: Peptide:
AdipoR₂	Agonists: Peptide: Adiponectin ; Non-peptide: AdipoRon Deoxyschizandrin Parthenolide Taxifoliol Antagonists: Peptide:

Angiotensin

See here instead.

Agonists: Bradykinin
Kallidin

Antagonists:
Icatibant
LF22-0542

CGRP

Agonists: Amylin
CGRP
Pramlintide

Antagonists: Atogepant
Olcegepant
Rimegepant
Telcagepant
Ubrogepant

Antibodies: Eptinezumab
Erenumab
Fremanezumab
Galcanezumab

Cholecystokinin

CCK_A	Agonists: Cholecystokinin Antagonists: Asperlicin Devazepide Dexloxiglumide Lorglumide Proglumide
CCK_B	Agonists: Cholecystokinin CCK-4 Gastrin Pentagastrin (CCK-5) Antagonists: CI-988 (PD-134308) Proglumide
Unsorted	Antagonists:

CRH

CRF₁	Agonists: Corticorelin Corticotropin-releasing hormone Sauvagine Urocortin Antagonists: Antalarmin Astressin-B CP-154,526 Emicerfont Hypericin Pexacerfont Verucerfont
CRF₂	Agonists: Corticorelin Corticotropin-releasing hormone Sauvagine Urocortin Antagonists: Astressin-B

Cytokine

See here instead.

Agonists: Endothelin 1
Endothelin 2
Endothelin 3
Sarafotoxin

Antagonists:
Ambrisentan
Atrasentan
Bosentan
BQ-123
BQ-788
Clazosentan
Darusentan
Macitentan
Sitaxentan
Tezosentan
Zibotentan

Galanin

GAL₁	Agonists: Galanin Galanin-like peptide Galmic Galnon Antagonists:
GAL₂	Agonists: Galanin Galanin-like peptide Galmic Galnon Antagonists:
GAL₃	Agonists: Galanin Galmic Galnon Antagonists: HT-2157 SNAP-37889

Ghrelin/GHS

See here instead.

GH

See here instead.

GHRH

See here instead.

GLP-1	Agonists: Albiglutide Dulaglutide Exenatide GLP-1 Liraglutide Lixisenatide Oxyntomodulin Semaglutide Taspoglutide
GLP-2	Agonists: GLP-2 Teduglutide
Others	Propeptides: Preproglucagon Proglucagon

Glucagon

Agonists: Dasiglucagon
Glucagon
Oxyntomodulin

Antagonists:

Propeptides: Preproglucagon
Proglucagon

GnRH

See here instead.

See here instead.

Growth factor

See here instead.

Insulin

Agonists: Chaetochromin (4548-G05)
Insulin-like growth factor 1
Insulin-like growth factor 2
Insulin
Insulin aspart
Insulin degludec
Insulin detemir
Insulin glargine
Insulin glulisine
Insulin lispro
Mecasermin
Mecasermin rinfabate

Antagonists:

Kinase inhibitors: Linsitinib

Antibodies: (against IGF-1 and IGF-2)

Kisspeptin

Agonists: Kisspeptin (kisspeptin-54, metastin)
MVT-602 (RVT-602, TAK-448)

Antagonists:

Leptin

Agonists: Leptin
Metreleptin

MCH₁	Agonists: Melanin-concentrating hormone Antagonists: ATC-0175 GW-803430 NGD-4715 SNAP-7941 SNAP-94847
MCH₂	Agonists: Melanin-concentrating hormone

See here instead.

Neuropeptide FF

Agonists:
Neuropeptide FF

Antagonists: BIBP-3226

Neuropeptide S

Agonists: Neuropeptide S

Antagonists: ML-154
SHA-68

Y₁	Agonists: Neuropeptide Y Peptide YY Antagonists: BIBP-3226
Y₂	Agonists: Neuropeptide Y Peptide YY Antagonists: BIIE-0246
Y₄	Agonists: Neuropeptide Y Pancreatic polypeptide Peptide YY Antagonists: UR-AK49
Y₅	Agonists: Neuropeptide Y Peptide YY Antagonists: Lu AA-33810 Velneperit (S-2367)

NTS₁	Agonists: Neurotensin Neuromedin N Antagonists: Meclinertant SR-142948
NTS₂	Agonists: Neurotensin Antagonists: Levocabastine SR-142948

Opioid

See here instead.

Orexin

See here instead.

Oxytocin

See here instead.

See here instead.

Agonists: Abaloparatide
Parathyroid hormone
Parathyroid hormone-related protein (PTHrP)
Teriparatide

Agonists: Insulin-like factor 3
Relaxin (, , 3)
Serelaxin

See here instead.

See here instead.

TRH

Agonists:
Protirelin
Taltirelin
TRH (TRF)

TSH

Agonists: Thyrotropin alfa
TSH (thyrotropin)

Vasopressin

See here instead.

VIP/PACAP

VIPR₁	Agonists: Peptide: PACAP VIP
VIPR₂	Agonists: Peptide: LBT-3627 PACAP VIP
PAC₁	Agonists: PACAP Antagonists:
Unsorted

Others

Exogenous: Lifitegrast (LFA-1 antagonist)

See also: Receptor/signaling modulators

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