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5,7-Dichlorokynurenic acid
Names
Preferred IUPAC name
5,7-Dichloro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid
Identifiers
3D model (JSmol )
ChemSpider
IUPHAR/BPS
UNII
InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
N Key: BGKFPRIGXAVYNX-UHFFFAOYSA-N
N InChI=1/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
Key: BGKFPRIGXAVYNX-UHFFFAOYAD
C1=C(C=C2C(=C1Cl)C(=O)C=C(N2)C(=O)O)Cl
Properties
C 10 H 5 Cl 2 N O 3
Molar mass
258.05 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N (what is Y N ?)
Infobox references
Chemical compound
5,7-Dichlorokynurenic acid (DCKA ) is a selective NMDA receptor antagonist acting at the glycine site of the NMDA receptor complex.[1]
See also [ ]
References [ ]
^ McNamara D, Smith EC, Calligaro DO, O'Malley PJ, McQuaid LA, Dingledine R. 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neuroscience Letters . 1990 Nov 27;120(1):17-20. PMID 2149877
AMPAR KAR NMDAR
See also: Receptor/signaling modulators
Metabotropic glutamate receptor modulators
Glutamate metabolism/transport modulators
Categories :
Enoic acids NMDA receptor antagonists Chloroarenes 4-Quinolones Nervous system drug stubs Hidden categories:
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