Budipine

Budipine
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	N04BX03 (WHO)
Identifiers
show IUPAC name 1-tert-butyl-4,4-diphenylpiperidine^[1]
CAS Number	57982-78-2^Y
PubChem CID	68778
ChemSpider	62021^Y
UNII	L9026OPI2Z
KEGG	D07306^Y
ChEMBL	ChEMBL334491^Y
CompTox Dashboard (EPA)	DTXSID20206709
ECHA InfoCard	100.055.494
Chemical and physical data
Formula	C₂₁H₂₇N
Molar mass	293.454 g·mol⁻¹
3D model (JSmol)	Interactive image
show SMILES c1(ccccc1)C3(c2ccccc2)CCN(C(C)(C)C)CC3
show InChI InChI=1S/C21H27N/c1-20(2,3)22-16-14-21(15-17-22,18-10-6-4-7-11-18)19-12-8-5-9-13-19/h4-13H,14-17H2,1-3H3^Y Key:QIHLUZAFSSMXHQ-UHFFFAOYSA-N^Y

Budipine (brand name Parkinsan) is an antiparkinson agent marketed for the treatment of Parkinson's disease.^[2]^[3][1]

While its exact mechanism of action is not well characterized,^[2] it is believed to be an NMDA receptor antagonist,^[4]^[5] but also promoting the synthesis of dopamine.^[6]

Because it provides additional benefits relative to existing treatments, it probably does not precisely mimic the mechanism of an existing known treatment.^[6]^[7]

References[]

^ Martndale: The Complete Drug Reference, 35th Ed.
^ Jump up to: ^a ^b Heinz Reichmann (October 2006). "Budipine in Parkinson's tremor". Journal of the Neurological Sciences. 248 (1–2): 53–55. doi:10.1016/j.jns.2006.05.039. PMID 16784759. S2CID 21540225.
^ H. Przuntek; T. Müller (1999). Clinical efficacy of budipine in Parkinson's disease. Journal of Neural Transmission. Supplementum. 56. pp. 75–82. doi:10.1007/978-3-7091-6360-3_3. ISBN 978-3-211-83275-2. PMID 10370903.
^ Kornhuber J., Herr B., Thome J., Riederer P. (1995). "The antiparkinsonian drug budipine binds to NMDA and sigma receptors in postmortem human brain tissue". Journal of Neural Transmission. Supplementum. 46: 127–133. PMID 8821048.CS1 maint: multiple names: authors list (link)
^ Gene C. Palmer (September 2001). "Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies". Current Drug Targets. 2 (3): 241–271. doi:10.2174/1389450013348335. PMID 11554551.
^ Jump up to: ^a ^b Przuntek H, Bittkau S, Bliesath H, et al. (May 2002). "Budipine provides additional benefit in patients with Parkinson disease receiving a stable optimum dopaminergic drug regimen". Arch. Neurol. 59 (5): 803–6. doi:10.1001/archneur.59.5.803. PMID 12020263.
^ Jenny C.E. Owen; Peter S. Whitton (October 2006). "Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular dopamine in the frontal cortex of freely moving rats". Brain Research. 1117 (1): 206–212. doi:10.1016/j.brainres.2006.07.039. PMID 16996043. S2CID 29177107.

show

Antiparkinson agents (N04)

show v t Ionotropic glutamate receptor modulators
AMPAR	Agonists: Main site agonists: 5-Fluorowillardiine AMPA Domoic acid Glutamate Ibotenic acid Proline Quisqualic acid Willardiine; Positive allosteric modulators: Aniracetam BIIB-104 (PF-04958242) Cyclothiazide CX-516 CX-546 CX-614 Farampator (CX-691, ORG-24448) CX-717 CX-1739 Diazoxide Hydrochlorothiazide (HCTZ) IDRA-21 LY-404187 LY-503430 Mibampator (LY-451395) Nooglutyl ORG-26576 Oxiracetam PEPA Piracetam Pramiracetam S-18986 Tulrampator (S-47445, CX-1632) Antagonists: Becampanel Caroverine CNQX Dasolampanel DNQX Fanapanel (MPQX) Kaitocephalin Kynurenic acid Kynurenine Licostinel (ACEA-1021) NBQX Selurampanel Tezampanel Theanine Topiramate Zonampanel; Negative allosteric modulators: Barbiturates (e.g., pentobarbital, sodium thiopental) Cyclopropane Enflurane Ethanol (alcohol) Evans blue GYKI-52466 Halothane Irampanel Isoflurane Perampanel Pregnenolone sulfate Sevoflurane Talampanel; Unknown/unsorted antagonists: Minocycline
KAR	Agonists: Main site agonists: 5-Iodowillardiine AMPA Domoic acid Glutamate Ibotenic acid Kainic acid Proline Quisqualic acid ; Positive allosteric modulators: Cyclothiazide Diazoxide Enflurane Halothane Isoflurane Antagonists: CNQX Dasolampanel DNQX Kaitocephalin Kynurenic acid Licostinel (ACEA-1021) NBQX NS102 Selurampanel Tezampanel Theanine Topiramate UBP-302; Negative allosteric modulators: Barbiturates (e.g., pentobarbital, sodium thiopental) Enflurane Ethanol (alcohol) Evans blue Pregnenolone sulfate
NMDAR	Agonists: Main site agonists: Aspartate Glutamate Homocysteic acid (L-HCA) Homoquinolinic acid Ibotenic acid NMDA Proline Quinolinic acid Tetrazolylglycine Theanine; Glycine site agonists: ACC (ACPC) ACPD Apimostinel (NRX-1074) D-Alanine D-Cycloserine D-Serine Dimethylglycine Glycine HA-966 L-Alanine L-Serine Milacemide Neboglamine (nebostinel) Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEA (prasterone) DHEA sulfate (prasterone sulfate) Pregnenolone sulfate Antagonists: Competitive antagonists: AP5 (APV) AP7 CGP-37849 Kaitocephalin LY-235959 Midafotel (d-CPPene) PEAQX Perzinfotel Selfotel; Glycine site antagonists: 4-Cl-KYN (AV-101) 5,7-DCKA 7-CKA ACC Apimostinel (NRX-1074) AV-101 Carisoprodol CNQX D-Cycloserine DNQX Felbamate Gavestinel Kynurenic acid Kynurenine Licostinel (ACEA-1021) Meprobamate Rapastinel (GLYX-13) ; Polyamine site antagonists: Diaminopropane Diethylenetriamine Huperzine A Putrescine; Uncompetitive pore blockers (mostly dizocilpine site): 2-MDP 3-HO-PCP 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP 4-MeO-PCP 8A-PDHQ 18-MC α-Endopsychosin Alaproclate Alazocine (SKF-10047) Amantadine Aptiganel Arketamine Budipine Coronaridine Delucemine (NPS-1506) Dexoxadrol Dextrallorphan Dextromethadone Dextromethorphan Dextrorphan Dieticyclidine Diphenidine Dizocilpine Ephenidine Esketamine Etoxadrol Eticyclidine Fluorolintane Gacyclidine Ibogaine Ibogamine Indantadol Ketamine Ketobemidone Lanicemine Levomethadone Levomethorphan Levomilnacipran Levorphanol Loperamide Memantine Methadone Methorphan Methoxetamine Methoxphenidine Milnacipran Morphanol NEFA Neramexane Nitromemantine Noribogaine Norketamine Orphenadrine PCPr PD-137889 Pethidine (meperidine) Phencyclamine Phencyclidine Propoxyphene Remacemide Rhynchophylline Rimantadine Rolicyclidine Sabeluzole Tabernanthine Tenocyclidine Tiletamine Tramadol; Ifenprodil (NR2B) site antagonists: Besonprodil Buphenine (nylidrin) Eliprodil Haloperidol Isoxsuprine Rislenemdaz (CERC-301, MK-0657) Traxoprodil (CP-101606); NR2A-selective antagonists: ; Cations: Hydrogen Magnesium Zinc; Alcohols/volatile anesthetics/related: Benzene Butane Chloroform Cyclopropane Desflurane Diethyl ether Enflurane Ethanol (alcohol) Halothane Hexanol Isoflurane Methoxyflurane Nitrous oxide Octanol Sevoflurane Toluene Trichloroethane Trichloroethanol Trichloroethylene Urethane Xenon Xylene; Unknown/unsorted antagonists: Bumetanide Caroverine Conantokin D-αAA Dexanabinol Flufenamic acid Flupirtine Furosemide Hodgkinsine Metaphit Minocycline MPEP Niflumic acid Pentamidine Pentamidine isethionate Piretanide Psychotridine Transcrocetin (saffron) Unsorted: Allosteric modulators: AGN-241751
See also: Receptor/signaling modulators Metabotropic glutamate receptor modulators Glutamate metabolism/transport modulators

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Budipine

See also[]

References[]