Irampanel ATC code
N ,N -Dimethyl-2-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenoxy]ethanamine
CAS Number PubChem CID ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) Formula C 18 H 19 N 3 O 2 Molar mass 309.369 g·mol−1 3D model (JSmol )
CN(C)CCOc1ccccc1c2nc(no2)c3ccccc3
InChI=1S/C18H19N3O2/c1-21(2)12-13-22-16-11-7-6-10-15(16)18-19-17(20-23-18)14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3
Key:QZULPCPLWGCGSL-UHFFFAOYSA-N
Irampanel (INN , code name BIIR-561 ) is a drug which acts as a dual noncompetitive antagonist of the AMPA receptor and neuronal voltage-gated sodium channel blocker .[1] [2] It was under development by Boehringer Ingelheim for the treatment of acute stroke /cerebral ischemia but never completed clinical trials for this indication.[3] [4] Irampanel was also trialed, originally, for the treatment of epilepsy and pain , but these indications, too, were abandoned,[1] and the drug was ultimately never marketed.
References [ ]
Anticonvulsants (N03 )
GABAergics
Channel modulators
Sodium blockers Calcium blockers
Oxazolidinediones : Ethadione
Paramethadione
Trimethadione ; Succinimides : Ethosuximide #
Mesuximide
Phensuximide ; Gabapentinoids : Gabapentin
Pregabalin ; Others: Imepitoin
Lamotrigine #
Topiramate
Zonisamide
Potassium openers
Others
CA inhibitors Others
Albutoin
Beclamide
Cannabidiol
Etiracetam
Levetiracetam
Perampanel
# WHO-EM
‡ Withdrawn from market
Clinical trials :
† Phase III
§ Never to phase III
Calcium
Potassium
VGKCs
Blockers
hERG (KCNH2, Kv 11.1)-specific: Ajmaline
Amiodarone
AmmTX3
Astemizole
Azaspiracid
AZD1305
Azimilide
Bedaquiline
BeKm-1
BmTx3
BRL-32872
Chlorpromazine
Cisapride
Clarithromycin
Darifenacin
Dextropropoxyphene
Diallyl trisulfide
Domperidone
E-4031
Ergtoxins
Erythromycin
Gigactonine
Haloperidol
Ketoconazole
Norpropoxyphene
Orphenadrine
Pimozide
PNU-282,987
Promethazine
Quinidine
Ranolazine
Roxithromycin
Sertindole
Solifenacin
Tamulotoxin
Terodiline
Terfenadine
Thioridazine
Tolterodine
Vanoxerine
Vernakalant
KCNQ (Kv 7) -specific: Linopirdine
Spooky toxin (SsTx)
Activators
KCNQ (Kv 7) -specific: Flupirtine
Retigabine
IRKs
Blockers
GIRK -specific: Barium
Caramiphen
Cloperastine
Clozapine
Dextromethorphan
Ethosuximide
Ifenprodil
Tertiapin
Tipepidine
Activators
KATP -specific:
Bimakalim
Cromakalim
Diazoxide
Levcromakalim
Minoxidil
Nicorandil
Pinacidil
KCa
Blockers
BKCa -specific: Ethanol (alcohol)
GAL-021
Activators
K2Ps
Blockers
12-O-Tetradecanoylphorbol-13-acetate
Arachidonic acid
Fluoxetine
Norfluoxetine
Activators
Sodium
VGSCs
Blockers
Antiarrhythmics (class I): Ajmaline
Aprindine
Disopyramide
Dronedarone
Encainide
Flecainide
Lidocaine
Lorajmine
Lorcainide
Mexiletine
Moricizine
Pilsicainide
Prajmaline
Procainamide
Propafenone
Quinidine
Sparteine
Tocainide
Analgesics:
DSP-2230
Funapide
PF-05089771
Ralfinamide
Raxatrigine
Toxins: Conotoxins
Neosaxitoxin
Saxitoxin
Tetrodotoxin
Zetekitoxin AB
Others: Buprenorphine
Evenamide
Menthol (mint )
Safinamide
Tricyclic antidepressants
Activators
ENaC
Blockers
Amiloride
Benzamil
Triamterene
Activators
ASICs
Blockers
Amiloride
Aspirin
Ibuprofen
Chloride
Others
See also: Receptor/signaling modulators • Transient receptor potential channel modulators
AMPAR KAR
Agonists: Main site agonists:
5-Iodowillardiine
AMPA
Domoic acid
Glutamate
Ibotenic acid
Kainic acid
Proline
Quisqualic acid
; Positive allosteric modulators: Cyclothiazide
Diazoxide
Enflurane
Halothane
Isoflurane
Antagonists:
CNQX
Dasolampanel
DNQX
Kaitocephalin
Kynurenic acid
Licostinel (ACEA-1021)
NBQX
NS102
Selurampanel
Tezampanel
Theanine
Topiramate
UBP-302 ; Negative allosteric modulators: Barbiturates (e.g., pentobarbital , sodium thiopental )
Enflurane
Ethanol (alcohol)
Evans blue
Pregnenolone sulfate
NMDAR
See also: Receptor/signaling modulators
Metabotropic glutamate receptor modulators
Glutamate metabolism/transport modulators