Farampator

Farampator
Clinical data


Other names	CX-691; ORG-24448
Legal status
Legal status	US: Investigational New Drug
Identifiers
show IUPAC name 2,1,3-benzoxadiazol-6-yl-piperidin-1-ylmethanone
CAS Number	211735-76-1^Y
PubChem CID	4118151
ChemSpider	3331565^N
UNII	7X6P5N8K2L
KEGG	D04131^Y
CompTox Dashboard (EPA)	DTXSID90175413
Chemical and physical data
Formula	C₁₂H₁₃N₃O₂
Molar mass	231.255 g·mol⁻¹
3D model (JSmol)	Interactive image
show SMILES C1CCN(CC1)C(=O)C2=CC3=NON=C3C=C2
show InChI InChI=1S/C12H13N3O2/c16-12(15-6-2-1-3-7-15)9-4-5-10-11(8-9)14-17-13-10/h4-5,8H,1-3,6-7H2^N Key:XFVRBYKKGGDPAJ-UHFFFAOYSA-N^N
^NY (what is this?)

Farampator (developmental code names CX-691, ORG-24448, SCH-900460) is an ampakine drug. It was developed by Cortex Pharmaceuticals, and licensed to Organon BioSciences for commercial development. Following the purchase of Organon by Schering-Plough in 2007, the development license to farampator was transferred. The development of farampator was eventually terminated, reportedly due to concerns about cardiac toxicity.^[1]^[2]

Farampator has been investigated for its effect on AMPA receptors and researched for potential use in the treatment of schizophrenia and Alzheimer's disease. It was found to improve short-term memory, but impaired episodic memory. It produced side effects such as headache, somnolence and nausea. Subjects reporting side effects had significantly higher plasma levels of farampator than subjects without.^{[citation needed]} Additional analyses revealed that in the farampator condition the group without side effects showed a significantly superior memory performance relative to the group with side effects.^[3]

References[]

^ http://adisinsight.springer.com/drugs/800012259
^ Froestl W, Muhs A, Pfeifer A (2012). "Cognitive enhancers (nootropics). Part 1: drugs interacting with receptors". J. Alzheimers Dis. 32 (4): 793–887. doi:10.3233/JAD-2012-121186. PMID 22886028.
^ Wezenberg E, Verkes RJ, Ruigt GS, Hulstijn W, Sabbe BG (Jun 2007). "Acute effects of the ampakine farampator on memory and information processing in healthy elderly volunteers". Neuropsychopharmacology. 32 (6): 1272–83. doi:10.1038/sj.npp.1301257. PMID 17119538.

show v t Ionotropic glutamate receptor modulators
AMPAR	Agonists: Main site agonists: 5-Fluorowillardiine AMPA Domoic acid Glutamate Ibotenic acid Proline Quisqualic acid Willardiine; Positive allosteric modulators: Aniracetam BIIB-104 (PF-04958242) Cyclothiazide CX-516 CX-546 CX-614 Farampator (CX-691, ORG-24448) CX-717 CX-1739 Diazoxide Hydrochlorothiazide (HCTZ) IDRA-21 LY-404187 LY-503430 Mibampator (LY-451395) Nooglutyl ORG-26576 Oxiracetam PEPA Piracetam Pramiracetam S-18986 Tulrampator (S-47445, CX-1632) Antagonists: Becampanel Caroverine CNQX Dasolampanel DNQX Fanapanel (MPQX) Kaitocephalin Kynurenic acid Kynurenine Licostinel (ACEA-1021) NBQX Selurampanel Tezampanel Theanine Topiramate Zonampanel; Negative allosteric modulators: Barbiturates (e.g., pentobarbital, sodium thiopental) Cyclopropane Enflurane Ethanol (alcohol) Evans blue GYKI-52466 Halothane Irampanel Isoflurane Perampanel Pregnenolone sulfate Sevoflurane Talampanel; Unknown/unsorted antagonists: Minocycline
KAR	Agonists: Main site agonists: 5-Iodowillardiine AMPA Domoic acid Glutamate Ibotenic acid Kainic acid Proline Quisqualic acid ; Positive allosteric modulators: Cyclothiazide Diazoxide Enflurane Halothane Isoflurane Antagonists: CNQX Dasolampanel DNQX Kaitocephalin Kynurenic acid Licostinel (ACEA-1021) NBQX NS102 Selurampanel Tezampanel Theanine Topiramate UBP-302; Negative allosteric modulators: Barbiturates (e.g., pentobarbital, sodium thiopental) Enflurane Ethanol (alcohol) Evans blue Pregnenolone sulfate
NMDAR	Agonists: Main site agonists: Aspartate Glutamate Homocysteic acid (L-HCA) Homoquinolinic acid Ibotenic acid NMDA Proline Quinolinic acid Tetrazolylglycine Theanine; Glycine site agonists: ACC (ACPC) ACPD Apimostinel (NRX-1074) D-Alanine D-Cycloserine D-Serine Dimethylglycine Glycine HA-966 L-Alanine L-Serine Milacemide Neboglamine (nebostinel) Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEA (prasterone) DHEA sulfate (prasterone sulfate) Pregnenolone sulfate Antagonists: Competitive antagonists: AP5 (APV) AP7 CGP-37849 Kaitocephalin LY-235959 Midafotel (d-CPPene) PEAQX Perzinfotel Selfotel; Glycine site antagonists: 4-Cl-KYN (AV-101) 5,7-DCKA 7-CKA ACC Apimostinel (NRX-1074) AV-101 Carisoprodol CNQX D-Cycloserine DNQX Felbamate Gavestinel Kynurenic acid Kynurenine Licostinel (ACEA-1021) Meprobamate Rapastinel (GLYX-13) ; Polyamine site antagonists: Diaminopropane Diethylenetriamine Huperzine A Putrescine; Uncompetitive pore blockers (mostly dizocilpine site): 2-MDP 3-HO-PCP 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP 4-MeO-PCP 8A-PDHQ 18-MC α-Endopsychosin Alaproclate Alazocine (SKF-10047) Amantadine Aptiganel Arketamine Budipine Coronaridine Delucemine (NPS-1506) Dexoxadrol Dextrallorphan Dextromethadone Dextromethorphan Dextrorphan Dieticyclidine Diphenidine Dizocilpine Ephenidine Esketamine Etoxadrol Eticyclidine Fluorolintane Gacyclidine Ibogaine Ibogamine Indantadol Ketamine Ketobemidone Lanicemine Levomethadone Levomethorphan Levomilnacipran Levorphanol Loperamide Memantine Methadone Methorphan Methoxetamine Methoxphenidine Milnacipran Morphanol NEFA Neramexane Nitromemantine Noribogaine Norketamine Orphenadrine PCPr PD-137889 Pethidine (meperidine) Phencyclamine Phencyclidine Propoxyphene Remacemide Rhynchophylline Rimantadine Rolicyclidine Sabeluzole Tabernanthine Tenocyclidine Tiletamine Tramadol; Ifenprodil (NR2B) site antagonists: Besonprodil Buphenine (nylidrin) Eliprodil Haloperidol Isoxsuprine Rislenemdaz (CERC-301, MK-0657) Traxoprodil (CP-101606); NR2A-selective antagonists: ; Cations: Hydrogen Magnesium Zinc; Alcohols/volatile anesthetics/related: Benzene Butane Chloroform Cyclopropane Desflurane Diethyl ether Enflurane Ethanol (alcohol) Halothane Hexanol Isoflurane Methoxyflurane Nitrous oxide Octanol Sevoflurane Toluene Trichloroethane Trichloroethanol Trichloroethylene Urethane Xenon Xylene; Unknown/unsorted antagonists: Bumetanide Caroverine Conantokin D-αAA Dexanabinol Flufenamic acid Flupirtine Furosemide Hodgkinsine Metaphit Minocycline MPEP Niflumic acid Pentamidine Pentamidine isethionate Piretanide Psychotridine Transcrocetin (saffron) Unsorted: Allosteric modulators: AGN-241751
See also: Receptor/signaling modulators Metabotropic glutamate receptor modulators Glutamate metabolism/transport modulators

This drug article relating to the nervous system is a stub. You can help Wikipedia by .

Farampator

See also[]

References[]