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The lysophosphatidic acid receptors (LPARs) are a group of G protein-coupled receptors for lysophosphatidic acid (LPA) that include:
- Lysophosphatidic acid receptor 1 (LPAR1; formerly known as EDG2, GPR26)
- Lysophosphatidic acid receptor 2 (LPAR2; formerly known as EDG4)
- Lysophosphatidic acid receptor 3 (LPAR3; formerly known as EDG7)
- Lysophosphatidic acid receptor 4 (LPAR4; formerly known as GPR23, P2RY9)
- Lysophosphatidic acid receptor 5 (LPAR5; formerly known as GPR92)
- Lysophosphatidic acid receptor 6 (LPAR6; formerly known as GPR87, P2RY5)
See also[]
References[]
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G protein–coupled receptor | Class A | |
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Class B | |
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Class C |
- Metabotropic glutamate receptor
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Class D | |
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Class E | |
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Class F | |
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Ligand-gated ion channel | |
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Enzyme-linked receptor | |
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Other/ungrouped | |
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Cell surface receptor: G protein-coupled receptors |
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Neurotransmitter | Adrenergic |
- α1 (A
- B
- D)
- α2 (A
- B
- C)
- β1
- β2
- β3
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Purinergic |
- Adenosine (A1
- A2A
- A2B
- A3)
- P2Y (1
- 2
- 4
- 5
- 6
- 8
- 9
- 10
- 11
- 12
- 13
- 14)
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Serotonin | |
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Other |
- Acetylcholine (M1
- M2
- M3
- M4
- M5)
- Dopamine
- GHB receptor
- Histamine
- Melatonin (1A
- 1B
- 1C)
- TAAR (1
- 2
- 5
- 6
- 8
- 9)
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Metabolites and signaling molecules | Eicosanoid |
- CysLT (1
- 2)
- LTB4
- FPRL1
- OXE
- Prostaglandin
- DP (1
- 2), EP (1
- 2
- 3
- 4), FP
- Prostacyclin
- Thromboxane
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Other |
- Bile acid
- Cannabinoid (CB1
- CB2, GPR (18
- 55
- 119))
- EBI2
- Estrogen
- Free fatty acid (1
- 2
- 3
- 4)
- Hydroxycarboxylic acids
- Lysophosphatidic acid (1
- 2
- 3
- 4
- 5
- 6)
- Lysophospholipid (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8)
- Oxoglutarate
- PAF
- Sphingosine-1-phosphate (1
- 2
- 3
- 4
- 5)
- Succinate
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Peptide | |
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Miscellaneous | |
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Taste, sweet | |
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Other |
- Calcium-sensing receptor
- GABAB (1
- 2)
- Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8))
- GPRC6A
- GPR (156
- 158
- 179)
- RAIG (1
- 2
- 3
- 4)
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Extracellular | Eicosanoids | |
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Lysophospholipids | |
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Steroids |
- Bile acids (GPBAR)
- Neurosteroids
- Pheromones (VNR)
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Others | |
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Intracellular | Nuclear receptor |
- Steroids: Sex steroids: Androgens (AR)
- Estrogens (ER)
- Progestogens (PR); Corticosteroids: Glucocorticoids (GR)
- Mineralocorticoids (MR); Others: Bile acids (FXR)
- Calcitriol (VDR); Others: Eicosanoids (PPAR)
- Free fatty acids (PPAR)
- Retinoic acid (RAR, RXR)
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Second messenger |
- General: Arachidonic acid
- DAG (PKC, TRPC)
- IP3 (IP3R, RyR)
- Phosphatidic acid
- Phosphoinositides: PIP2 (IRKs)
- PIP3 (PKB/Akt, Btk, PDPK1)
- PtdIns(3,4)P2 (PKB/Akt, PDPK1); Sphingolipids:
- Ceramide (CAPPs, KSR1, PKCζ, CTSD)
- Glucosylceramides
- S1P
- Sphingosine (, , )
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Precursors | General | |
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Steroids |
- Squalene
- Lanosterol
- Cholesterol
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Receptor (ligands) | LPAR | |
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S1PR |
- Agonists:
- Fingolimod
- Ponesimod
- Siponimod
- S1P
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Enzyme (inhibitors) | |
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Others |
- Precursors: LPA: LPC; S1P: Palmitoyl-CoA
- Serine
- Dihydrosphingosine (sphinganine)
- Ceramide
- Sphingosine
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See also: Receptor/signaling modulators |
Categories:
- G protein-coupled receptors
- Biochemistry stubs