Leukotriene receptor
The leukotriene (LT) receptors are G protein-coupled receptors that bind and are activated by the leukotrienes. They include the following proteins:
- Leukotriene B4 receptors (BLTRs) – bind to and are activated by LTB4:
- BLT1 (Leukotriene B4 receptor 1) – LTB4R
- BLT2 (Leukotriene B4 receptor 2) – LTB4R2
- Cysteinyl leukotriene receptors (CysLTRs) – bind to and are activated by LTC4, LTD4, and LTE4:
The recently elucidated CysLTE, represented by GPR99/OXGR1, may constitute a third CysLTR.[1]
See also[]
- Eicosanoid receptor
- Oxoeicosanoid receptor
- Prostaglandin receptor
- Thromboxane receptor
References[]
- ^ Kanaoka Y, Maekawa A, Austen KF (2013). "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand". J. Biol. Chem. 288 (16): 10967–72. doi:10.1074/jbc.C113.453704. PMC 3630866. PMID 23504326.
External links[]
- IUPHAR GPCR Database – Leukotriene receptors
- Leukotriene+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
Categories:
- Eicosanoids
- G protein-coupled receptors
- Biochemistry stubs