CELSR3

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CELSR3
Identifiers
AliasesCELSR3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1, ADGRC3, cadherin EGF LAG seven-pass G-type receptor 3
External IDsOMIM: 604264 MGI: 1858236 HomoloGene: 1077 GeneCards: CELSR3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001407

NM_080437

RefSeq (protein)

NP_001398

NP_536685
NP_001346501
NP_001346502

Location (UCSC)Chr 3: 48.64 – 48.66 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.[4][5]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.[5]

See also[]

References[]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000008300 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
  5. ^ a b "Entrez Gene: CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)".

Further reading[]

External links[]

  • Human CELSR3 genome location and CELSR3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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