FZD5

FZD5
Identifiers
Aliases	FZD5, C2orf31, HFZ5, frizzled class receptor 5
External IDs	OMIM: 601723 MGI: 108571 HomoloGene: 2590 GeneCards: FZD5
Gene location (Human)
Chr.	Chromosome 2 (human)
End	207,769,906 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	64,737,751 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• amyloid-beta binding; • signal transducer activity; • Wnt-protein binding; • GO:0001948 protein binding; • protein kinase binding; • ubiquitin protein ligase binding; • transmembrane signaling receptor activity; • Wnt-activated receptor activity; • G protein-coupled receptor activity;
Cellular component	• clathrin-coated endocytic vesicle membrane; • Golgi apparatus; • early endosome membrane; • membrane; • bicellular tight junction; • Golgi membrane; • plasma membrane; • cell surface; • early endosome; • perinuclear region of cytoplasm; • integral component of membrane;
Biological process	• G protein-coupled receptor signaling pathway; • T cell differentiation in thymus; • chorionic trophoblast cell differentiation; • positive regulation of protein targeting to mitochondrion; • positive regulation of JUN kinase activity; • apoptotic process involved in morphogenesis; • regulation of chorionic trophoblast cell proliferation; • regulation of bicellular tight junction assembly; • regulation of canonical Wnt signaling pathway; • cellular response to molecule of bacterial origin; • positive regulation of interferon-gamma production; • embryonic axis specification; • labyrinthine layer blood vessel development; • cell maturation; • Wnt signaling pathway; • embryonic camera-type eye development; • multicellular organism development; • cell surface receptor signaling pathway; • vasculature development; • regulation of autophagy of mitochondrion; • branching involved in labyrinthine layer morphogenesis; • embryonic camera-type eye morphogenesis; • post-embryonic camera-type eye development; • positive regulation of T cell cytokine production; • angiogenesis; • neuron differentiation; • Wnt signaling pathway involved in dorsal/ventral axis specification; • canonical Wnt signaling pathway; • synapse assembly; • syncytiotrophoblast cell differentiation involved in labyrinthine layer development; • anterior/posterior axis specification, embryo; • Spemann organizer formation; • positive regulation of transcription by RNA polymerase II; • negative regulation of cell population proliferation; • signal transduction; • Wnt signaling pathway, calcium modulating pathway; • Wnt signaling pathway, planar cell polarity pathway; • beta-catenin destruction complex disassembly;
	Sources:Amigo / QuickGO
Orthologs
	7855
	14367
	ENSG00000163251
	ENSMUSG00000045005
	Q13467
	Q9EQD0
	NM_030804; NM_003468
	NM_001033193; NM_001042659; NM_022721
	NP_003459
	NP_001036124; NP_073558
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.^[5]^[6]^[7]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163251 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045005 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J Biol Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.
^ Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region". Int J Oncol. 19 (1): 105–10. doi:10.3892/ijo.19.1.105. PMID 11408929.
^ ^a ^b "Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)".

External links[]

"Frizzled Receptors: FZD₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163251 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045005 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8626800-5] Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J Biol Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.

[pmid11408929-6] Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region". Int J Oncol. 19 (1): 105–10. doi:10.3892/ijo.19.1.105. PMID 11408929.

[entrez-7] "Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)".

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FZD5

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