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ADGRF5 Identifiers Aliases ADGRF5 , KPG_001, GPR116, adhesion G protein-coupled receptor F5External IDs MGI : 2182928 HomoloGene : 9065 GeneCards : ADGRF5 Gene location (Human ) Chr. Chromosome 6 (human) [1] Band 6p12.3 Start 46,852,522 bp [1] End 46,954,943 bp [1]
Gene location (Mouse ) Chr. Chromosome 17 (mouse)[2] Band 17|17 B3 Start 43,360,451 bp [2] End 43,459,557 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 6: 46.85 – 46.95 Mb Chr 17: 43.36 – 43.46 Mb PubMed search[3] [4] Wikidata
Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene .[5] [6] [7] GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.[8] [9]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000069122 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056492 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Stacey, edited by S Yona, M Stacey (2010). Adhesion-GPCRs : structure to function . New York: Springer Science+Business Media. ISBN 978-1-4419-7912-4 .
^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions" . FEBS Letters . 531 (3): 407–14. doi :10.1016/S0014-5793(02)03574-3 . PMID 12435584 . S2CID 7449692 .
^ "Entrez Gene: GPR116 G protein-coupled receptor 116" .
^ Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B (May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116" . Cell Reports . 3 (5): 1457–64. doi :10.1016/j.celrep.2013.04.019 . PMC 3695742 . PMID 23684610 .
^ Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S (2013). "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D" . PLOS ONE . 8 (7): e69451. Bibcode :2013PLoSO...869451F . doi :10.1371/journal.pone.0069451 . PMC 3726689 . PMID 23922714 .
Further reading [ ]
Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse" . Proceedings of the National Academy of Sciences of the United States of America . 100 (8): 4903–8. Bibcode :2003PNAS..100.4903V . doi :10.1073/pnas.0230374100 . PMC 153653 . PMID 12679517 .
Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics . 84 (1): 23–33. doi :10.1016/j.ygeno.2003.12.004 . PMID 15203201 .
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Research . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 . PMID 15489336 .
Cell surface receptor : G protein-coupled receptors
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