GPR177

From Wikipedia, the free encyclopedia
WLS
Identifiers
AliasesWLS, C1orf139, EVI, GPR177, MRP, mig-14, wntless Wnt ligand secretion mediator, Wnt ligand secretion mediator, ZKS
External IDsOMIM: 611514 MGI: 1915401 HomoloGene: 11779 GeneCards: WLS
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002292
NM_001193334
NM_024911

NM_026582
NM_001356349
NM_001356350

RefSeq (protein)

NP_001002292
NP_001180263
NP_079187

NP_080858
NP_001343278
NP_001343279

Location (UCSC)Chr 1: 68.1 – 68.23 MbChr 3: 159.84 – 159.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G protein-coupled receptor 177 (GPR177), commonly known as Wntless, is a human gene[5] that encodes a receptor for Wnt proteins in Wnt-secreting cells.[6]

Wntless was shown to be a cargo for the retromer complex.[6] It has been found essential for hair follicle induction.[7]

A homozygous missense mutation in the WLS gene was identified in Zaki syndrome.[8]

References[]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116729 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028173 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GPR177 G protein-coupled receptor 177".
  6. ^ a b Eaton S (January 2008). "Retromer retrieves wntless". Developmental Cell. 14 (1): 4–6. doi:10.1016/j.devcel.2007.12.014. PMID 18194646.
  7. ^ Fu J, Hsu W (April 2013). "Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis". The Journal of Investigative Dermatology. 133 (4): 890–8. doi:10.1038/jid.2012.407. PMC 3594635. PMID 23190887.
  8. ^ Chai, Guoliang; Szenker-Ravi, Emmanuelle; Chung, Changuk; Li, Zhen; Wang, Lu; Khatoo, Muznah; Marshall, Trevor; Jiang, Nan; Yang, Xiaoxu; McEvoy-Venneri, Jennifer; Stanley, Valentina (2021-09-29). "A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion". New England Journal of Medicine. doi:10.1056/NEJMoa2033911.

Further reading[]

See also[]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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