Hydroxycarboxylic acid receptor 3 (HCA3), also known as niacin receptor 2 (NIACR2) and GPR109B,[3] is a protein which in humans is encoded by the HCAR3gene.[4][5] HCA3, like the other hydroxycarboxylic acid receptorsHCA1 and HCA2, is a Gi/o-coupledG protein-coupled receptor (GPCR).[6][7] The primary endogenousagonists of HCA3 are 3-hydroxyoctanoic acid and kynurenic acid.[6][7][8] HCA3 is also a low-affinitybiomolecular target for niacin (aka nicotinic acid).[9]
^ Jump up to: abS Offermanns, SL Colletti, AP IJzerman, TW Lovenberg, G Semple, A Wise, MG Waters. "Hydroxycarboxylic acid receptors". IUPHAR/BPS Guide to Pharmacology. International Union of Basic and Clinical Pharmacology. Retrieved 13 July 2018.CS1 maint: multiple names: authors list (link)
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