Motilin receptor

MLNR
Identifiers
Aliases	MLNR, GPR38, MTLR1, motilin receptor
External IDs	OMIM: 602885 HomoloGene: 74398 GeneCards: MLNR
Gene location (Human)
Chr.	Chromosome 13 (human)
End	49,222,377 bp
RNA expression pattern
	Top expressed in
	fundus; ; stomach; ; bone marrow; ; thyroid gland; ; body of stomach; ; temporal lobe; ; kidney; ; heart; ; pancreas; ; uterus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	growth hormone-releasing hormone receptor activity; signal transducer activity; G protein-coupled receptor activity; G protein-coupled peptide receptor activity; hormone binding;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2862
	n/a
	ENSG00000102539
	n/a
	O43193
	n/a
	NM_001507
	n/a
	NP_001498
	n/a
	Wikidata
View/Edit Human

Motilin receptor is a G protein-coupled receptor that binds motilin.^[3]^[4] Motilin in turn is an intestinal peptide that stimulates contraction of gut smooth muscle.

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102539 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Depoortere I (2001). "Motilin and motilin receptors: characterization and functional significance". Verh. K. Acad. Geneeskd. Belg. 63 (6): 511–29. PMID 11813507.
^ Yang X, Dong L, Yang H (2006). "[Evidence for the presence of motilin receptor and a study on the mechanism of motilin induced Ca2+ signaling in rat myenteric neurons]". Sichuan da Xue Xue Bao Yi Xue Ban (in Chinese). 37 (5): 683–6. PMID 17037727.

Further reading[]

Smith RG, Leonard R, Bailey AR, et al. (2001). "Growth hormone secretagogue receptor family members and ligands". Endocrine. 14 (1): 9–14. doi:10.1385/ENDO:14:1:009. PMID 11322507. S2CID 31807893.
McKee KK, Tan CP, Palyha OC, et al. (1998). "Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors". Genomics. 46 (3): 426–34. doi:10.1006/geno.1997.5069. PMID 9441746.
Feighner SD, Tan CP, McKee KK, et al. (1999). "Receptor for motilin identified in the human gastrointestinal system". Science. 284 (5423): 2184–8. doi:10.1126/science.284.5423.2184. PMID 10381885.
Miller P, Roy A, St-Pierre S, et al. (2000). "Motilin receptors in the human antrum". Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1): G18–23. doi:10.1152/ajpgi.2000.278.1.G18. PMID 10644557.
Thielemans L, Depoortere I, Van Assche G, et al. (2001). "Demonstration of a functional motilin receptor in TE671 cells from human cerebellum". Brain Res. 895 (1–2): 119–28. doi:10.1016/S0006-8993(01)02055-8. PMID 11259768. S2CID 19864565.
Coulie B, Matsuura B, Dong M, et al. (2001). "Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling". J. Biol. Chem. 276 (38): 35518–22. doi:10.1074/jbc.M104489200. PMID 11461914.
Thielemans L, Depoortere I, Vanden Broeck J, Peeters TL (2002). "The motilin pharmacophore in CHO cells expressing the human motilin receptor". Biochem. Biophys. Res. Commun. 293 (4): 1223–7. doi:10.1016/S0006-291X(02)00356-X. PMID 12054506.
Depoortere I, Thijs T, Thielemans L, et al. (2003). "Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum". J. Pharmacol. Exp. Ther. 305 (2): 660–7. doi:10.1124/jpet.102.047563. PMID 12606621. S2CID 2078474.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Matsuura B, Dong M, Naik S, et al. (2006). "Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity". J. Biol. Chem. 281 (18): 12390–6. doi:10.1074/jbc.M511921200. PMID 16531413.

External links[]

"Motilin Receptors: Motilin". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Motilin+receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102539 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11813507-3] Depoortere I (2001). "Motilin and motilin receptors: characterization and functional significance". Verh. K. Acad. Geneeskd. Belg. 63 (6): 511–29. PMID 11813507.

[pmid17037727-4] Yang X, Dong L, Yang H (2006). "[Evidence for the presence of motilin receptor and a study on the mechanism of motilin induced Ca2+ signaling in rat myenteric neurons]". Sichuan da Xue Xue Bao Yi Xue Ban (in Chinese). 37 (5): 683–6. PMID 17037727.

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