Neuromedin B receptor

NMBR
Identifiers
Aliases	NMBR, BB1, NMB-R, neuromedin B receptor, BB1R, BRS1
External IDs	OMIM: 162341 MGI: 1100525 HomoloGene: 20560 GeneCards: NMBR
Gene location (Human)
Chr.	Chromosome 6 (human)
End	142,147,122 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• G protein-coupled peptide receptor activity; • signal transducer activity; • G protein-coupled receptor activity; • bombesin receptor activity;
Cellular component	• integral component of plasma membrane; • membrane; • integral component of membrane; • plasma membrane; • cytosol;
Biological process	• phospholipase C-activating G protein-coupled receptor signaling pathway; • bombesin receptor signaling pathway; • signal transduction; • G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4829
	18101
	ENSG00000135577
	ENSMUSG00000019865
	P28336
	O54799
	NM_002511; NM_001324307; NM_001324308
	NM_008703
	NP_001311236; NP_001311237; NP_002502
	NP_032729
	Wikidata
View/Edit Human	View/Edit Mouse

The neuromedin B receptor (NMBR), now known as BB₁ ^[4] is a G protein-coupled receptor whose endogenous ligand is neuromedin B.^[5] In humans, this protein is encoded by the NMBR gene.

Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135577 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Bombesin Receptors: BB₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
^ Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118.
^ "Entrez Gene: NMBR neuromedin B receptor".

Further reading[]

Corjay MH, Dobrzanski DJ, Way JM, et al. (1991). "Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells". J. Biol. Chem. 266 (28): 18771–9. doi:10.1016/S0021-9258(18)55129-2. PMID 1655761.
Wu JM, Hoang DO, Feldman RI (1995). "Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs". Mol. Pharmacol. 47 (4): 871–81. PMID 7723750.
Benya RV, Kusui T, Pradhan TK, et al. (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118.
Bitar KN, Zhu XX (1994). "Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction". Gastroenterology. 105 (6): 1672–80. doi:10.1016/0016-5085(93)91062-m. PMID 8253343.
Giladi E, Nagalla SR, Spindel ER (1993). "Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides". J. Mol. Neurosci. 4 (1): 41–54. doi:10.1007/BF02736689. PMID 8391296. S2CID 20854144.
Fathi Z, Benya RV, Shapira H, et al. (1993). "The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding". J. Biol. Chem. 268 (20): 14622–6. doi:10.1016/S0021-9258(18)82378-X. PMID 8392057.
Kane MA, Toi-Scott M, Johnson GL, et al. (1996). "Bombesin-like peptide receptors in human bronchial epithelial cells". Peptides. 17 (1): 111–8. doi:10.1016/0196-9781(95)02088-8. PMID 8822519. S2CID 30893871.
Sainz E, Akeson M, Mantey SA, et al. (1998). "Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor". J. Biol. Chem. 273 (26): 15927–32. doi:10.1074/jbc.273.26.15927. PMID 9632639.
Lee S, Kim Y (1999). "Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy". FEBS Lett. 460 (2): 263–9. doi:10.1016/S0014-5793(99)01346-0. PMID 10544247. S2CID 46035151.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Matusiak D, Glover S, Nathaniel R, et al. (2005). "Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G718–28. doi:10.1152/ajpgi.00156.2004. PMID 15528253.

External links[]

"Bombesin Receptors: BB₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Receptors,+Bombesin at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135577 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[IUPHAR-DB-4] "Bombesin Receptors: BB₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

[pmid7838118-5] Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118.

[entrez-6] "Entrez Gene: NMBR neuromedin B receptor".

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