Putative trace amine-associated receptor 3 (TAAR3) is a human pseudogene with the gene symbolTAAR3P.[3][4][5][6] In other species such as mice, TAAR3 is a functional protein-coding gene that encodes a trace amine-associated receptor protein.
Ligands:
Isobutylamine is a known ligand of TAAR3 in mice associated with sexual behaviour in male mice.[7]
was identified as a ligand for murine TAAR3 eliciting aversive behavior.[8]
^Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, et al. (February 2000). "Cloning and characterization of additional members of the G protein-coupled receptor family". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1490 (3): 311–23. doi:10.1016/s0167-4781(99)00241-9. PMID10684976.
^Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID15718104.
† References for all endogenous human TAAR1 ligands are provided at List of trace amines
‡ References for synthetic TAAR1 agonists can be found at TAAR1 or in the associated compound articles. For TAAR2 and TAAR5 agonists and inverse agonists, see TAAR for references.
See also:Receptor/signaling modulators
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Cell surface receptor: G protein-coupled receptors