KCNIP1 Available structures PDB Ortholog search: PDBe RCSB
Identifiers Aliases KCNIP1 , KCHIP1, VABP, potassium voltage-gated channel interacting protein 1External IDs OMIM : 604660 MGI : 1917607 HomoloGene : 22824 GeneCards : KCNIP1 show Gene location (Human )Chr. Chromosome 5 (human) [1] Band 5q35.1 Start 170,353,487 bp [1] End 170,736,632 bp [1]
show Gene location (Mouse )Chr. Chromosome 11 (mouse)[2] Band 11|11 A4 Start 33,629,339 bp [2] End 33,993,152 bp [2]
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 5: 170.35 – 170.74 Mb Chr 11: 33.63 – 33.99 Mb PubMed search[3] [4] Wikidata
Kv channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene .[5] [6]
Function [ ]
This gene encodes a member of the family of voltage-gated potassium (Kv ) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus . They are integral subunit components of native Kv 4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[6]
See also [ ]
Voltage-gated potassium channel
References [ ]
^ Jump up to: a b c GRCh38: Ensembl release 89: ENSG00000182132 - Ensembl , May 2017
^ Jump up to: a b c GRCm38: Ensembl release 89: ENSMUSG00000053519 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature . 403 (6769): 553–556. Bibcode :2000Natur.403..553A . doi :10.1038/35000592 . PMID 10676964 . S2CID 4419472 .
^ Jump up to: a b "Entrez Gene: KCNIP1 Kv channel interacting protein 1" .
^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling" . Nat. Rev. Neurosci . 8 (3): 182–193. doi :10.1038/nrn2093 . PMC 1887812 . PMID 17311005 .
Further reading [ ]
Bähring R, Dannenberg J, Peters HC, et al. (2001). "Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating" . J. Biol. Chem . 276 (26): 23888–23894. doi :10.1074/jbc.M101320200 . PMID 11287421 .
Nakamura TY, Nandi S, Pountney DJ, et al. (2001). "Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2" . FEBS Lett . 499 (3): 205–209. doi :10.1016/S0014-5793(01)02560-1 . PMID 11423117 . S2CID 23908034 .
Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome" . Nucleic Acids Res . 30 (14): 3163–3170. doi :10.1093/nar/gkf428 . PMC 135748 . PMID 12136098 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Shibata R, Misonou H, Campomanes CR, et al. (2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels" . J. Biol. Chem . 278 (38): 36445–36454. doi :10.1074/jbc.M306142200 . PMID 12829703 .
Van Hoorick D, Raes A, Keysers W, et al. (2004). "Differential modulation of Kv4 kinetics by KCHIP1 splice variants". Mol. Cell. Neurosci . 24 (2): 357–366. doi :10.1016/S1044-7431(03)00174-X . PMID 14572458 . S2CID 40647616 .
Scannevin RH, Wang K, Jow F, et al. (2004). "Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1" . Neuron . 41 (4): 587–598. doi :10.1016/S0896-6273(04)00049-2 . PMID 14980207 . S2CID 17380435 .
Lin YL, Lin SR, Wu TT, Chang LS (2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochem. Biophys. Res. Commun . 319 (3): 720–724. doi :10.1016/j.bbrc.2004.05.064 . PMID 15184042 .
Lin YL, Chen CY, Cheng CP, Chang LS (2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochem. Biophys. Res. Commun . 321 (3): 606–610. doi :10.1016/j.bbrc.2004.07.006 . PMID 15358149 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Pruunsild P, Timmusk T (2005). "Structure, alternative splicing, and expression of the human and mouse KCNIP gene family". Genomics . 86 (5): 581–593. doi :10.1016/j.ygeno.2005.07.001 . PMID 16112838 .
Pioletti M, Findeisen F, Hura GL, Minor DL (2007). "Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer" . Nat. Struct. Mol. Biol . 13 (11): 987–995. doi :10.1038/nsmb1164 . PMC 3018330 . PMID 17057713 . CS1 maint: multiple names: authors list (link )
Hasdemir B, Fitzgerald DJ, Prior IA, Tepikin AV, Burgoyne RD (2005). "Traffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway" . J. Cell Biol . 171 (3): 459–469. doi :10.1083/jcb.200506005 . PMC 2171252 . PMID 16260497 .
Venn N, Haynes LP, Burgoyne RD (2008). "Specific effects of KChIP3/calsenilin/DREAM but not KChIPs1, 2 and 4 on calcium signalling and regulated secretion in PC12 cells" . Biochem. J . 413 (1): 71–80. doi :10.1042/BJ20080441 . PMC 2474559 . PMID 18393943 .
External links [ ]
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
show PDB gallery
1s1e : Crystal Structure of Kv Channel-interacting protein 1 (KChIP-1)
1s6c : Crystal structure of the complex between KChIP1 and Kv4.2 N1-30
2i2r : Crystal structure of the KChIP1/Kv4.3 T1 complex
2nz0 : Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)
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