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KCNV1 Identifiers Aliases KCNV1 , HNKA, KCNB3, KV2.3, KV8.1, potassium voltage-gated channel modifier subfamily V member 1External IDs OMIM : 608164 MGI : 1914748 HomoloGene : 22811 GeneCards : KCNV1 Gene location (Human ) Chr. Chromosome 8 (human) [1] Band 8q23.2 Start 109,963,636 bp [1] End 109,975,771 bp [1]
Gene location (Mouse ) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.3 Start 45,106,284 bp [2] End 45,114,920 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 8: 109.96 – 109.98 Mb Chr 15: 45.11 – 45.11 Mb PubMed search[3] [4] Wikidata
Potassium voltage-gated channel subfamily V member 1 is a protein that in humans is encoded by the KCNV1 gene .[5] [6] The protein encoded by this gene is a voltage-gated potassium channel subunit.[5] [6]
Common variations in the KCNV1 gene have been associated with schizophrenia.[7]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000164794 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022342 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ a b Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattei MG, Lazdunski M (Aug 1996). "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels" . EMBO J . 15 (13): 3322–31. doi :10.1002/j.1460-2075.1996.tb00697.x . PMC 451895 . PMID 8670833 .
^ a b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev . 57 (4): 473–508. doi :10.1124/pr.57.4.10 . PMID 16382104 . S2CID 219195192 .
^ Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014-07-24). "Biological insights from 108 schizophrenia-associated genetic loci" . Nature . 511 (7510): 421–427. Bibcode :2014Natur.511..421S . doi :10.1038/nature13595 . ISSN 1476-4687 . PMC 4112379 . PMID 25056061 .
Further reading [ ]
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Sano A, Mikami M, Nakamura M, et al. (2002). "Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy" . Epilepsia . 43 Suppl 9: 26–31. doi :10.1046/j.1528-1157.43.s.9.7.x . PMID 12383276 . S2CID 39236204 .
Ebihara M, Ohba H, Kikuchi M, Yoshikawa T (2004). "Structural characterization and promoter analysis of human potassium channel Kv8.1 (KCNV1) gene". Gene . 325 : 89–96. doi :10.1016/j.gene.2003.09.044 . PMID 14697513 .
Salinas M, de Weille J, Guillemare E, et al. (1997). "Modes of regulation of shab K+ channel activity by the Kv8.1 subunit" . J. Biol. Chem . 272 (13): 8774–80. doi :10.1074/jbc.272.13.8774 . PMID 9079713 .
External links [ ]
Ligand-gated Voltage-gated
α2 δ-subunits
β-subunits
γ-subunits
Na+ : Sodium channel
Constitutively active
Epithelial sodium channel
Proton -gated
Amiloride-sensitive cation channel
Voltage-gated
Nav α
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
7A
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K+ : Potassium channel
Calcium-activated Inward-rectifier Tandem pore domain Voltage-gated
Miscellaneous
Cl− : Chloride channel
Calcium-activated chloride channels
Anoctamin
Bestrophin
Chloride Channel Accessory
CFTR
CLCN
CLIC
CLNS
H+ : Proton channel M+ : CNG cation channel M+ : TRP cation channel H2 O (+ solutes ): Porin Cytoplasm : Gap junction
see also disorders
Categories :
Genes on human chromosome 8 Ion channels Membrane protein stubs Hidden categories:
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