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PKD2L2 Identifiers Aliases PKD2L2 , TRPP5, polycystin 2 like 2, transient receptor potential cation channelExternal IDs OMIM : 604669 MGI : 1858231 HomoloGene : 22812 GeneCards : PKD2L2 Gene location (Human ) Chr. Chromosome 5 (human) [1] Band 5q31.2 Start 137,887,968 bp [1] End 137,942,747 bp [1]
Gene location (Mouse ) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 34,541,542 bp [2] End 34,577,169 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 5: 137.89 – 137.94 Mb Chr 18: 34.54 – 34.58 Mb PubMed search[3] [4] Wikidata
Polycystic kidney disease 2-like 2 protein (PKD2L2) also known as transient receptor potential polycystic 5 (TRPP5) is a protein that in humans is encoded by the PKD2L2 gene .[5]
TRPP5 is a member of the transient receptor potential channel family of proteins.
See also [ ]
References [ ]
Further reading [ ]
Li Q, Liu Y, Zhao W, Chen XZ (2002). "The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation" . FEBS Lett . 516 (1–3): 270–8. doi :10.1016/S0014-5793(02)02513-9 . PMID 11959145 . S2CID 1812119 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Stayner C, Zhou J (2001). "Polycystin channels and kidney disease". Trends Pharmacol. Sci . 22 (11): 543–6. doi :10.1016/S0165-6147(00)01832-0 . PMID 11698076 .
Guo L, Schreiber TH, Weremowicz S, et al. (2000). "Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization". Genomics . 64 (3): 241–51. doi :10.1006/geno.2000.6131 . PMID 10756092 .
Ligand-gated Voltage-gated
α2 δ-subunits
β-subunits
γ-subunits
Na+ : Sodium channel
Constitutively active
Epithelial sodium channel
Proton -gated
Amiloride-sensitive cation channel
Voltage-gated
Nav α
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
7A
Nav β
K+ : Potassium channel
Calcium-activated Inward-rectifier Tandem pore domain Voltage-gated
Miscellaneous
Cl− : Chloride channel
Calcium-activated chloride channels
Anoctamin
Bestrophin
Chloride Channel Accessory
CFTR
CLCN
CLIC
CLNS
H+ : Proton channel M+ : CNG cation channel M+ : TRP cation channel H2 O (+ solutes ): Porin Cytoplasm : Gap junction
see also disorders
Categories :
Genes on human chromosome 5 Ion channels Membrane protein stubs